Why are physicians prescribing vitamin D2 instead of D3?Vitamin D is a fat-soluble vitamin that promotes calcium intake that regulates bone growth¹ and plays a role in immune function. There are two main forms:
- Vitamin D2 (Ergocalciferol)
- Vitamin D3 (Cholecalciferol)
The difference between vitamin D2 and D3 is mainly in the sources from which they come from:
Vitamin D3 comes only in foods of animal origin before ¹, such as. B:
- Fish like salmon, tuna, sardines and mackerel;
The meaning of cutaneous vitamin D3 synthesisIn addition to the presentation of the difference between vitamin D2 and D3 in terms of their sources, it is important here the peculiarity of D3 with regard to its production by sunlight. This is one of the most important methods for obtaining this vital nutrient. In countries with good sun radiation, 90 to 95% of the vitamin D can be obtained by cutaneous synthesis.
Vitamin D3 from the connection
But how does it happen? The ultraviolet B radiation (UVB) of the sunlight solves the formation of Vitamin D3 From the connection 7-dehydrocholesterin in the skin off¹. So if you are regular in bright clothes and without sunscreen outdoors, you may receive the entire vitamin D needs. However, several factors can be the "quality" of the UVB rays for the production of Vitamin D3 Through the skin influence: Many people get little sun because they work in closed rooms throughout the day;
- The use of sunscreens (required daily to avoid injury due to excessive sunlight);
- Climate and environmental conditions - location, pollution, the season. For example, people who live in a country where there is not much sunlight in winter.
- In addition, the best sunty for vitamin D is between 10am and 4pm, so exactly the time that has most with skin cancer and premature aging.
- Therefore, you should be careful when you expose yourself to sunlight:
- Make sure you do not spend too much time in the sun. 10 to 15 minutes a day are sufficient;
- Leave arms and legs free, but protect sensitive places like face and neck.
Vitamin D2 and D3: What is better for your health?
- Both vitamin D2 and D3 have significant functions for your health. However, some studies are not equivalent when it comes to increase the vitamin D5 mirror.
- Both are effectively absorbed into the bloodstream. However, they are metabolized differently from the liver. But what does that mean?
- Vitamin D2 (Ergocalciferol) and D3 (cholecalciferol) must be processed by the body to get into their metabolically active form, the calcitriol.
- For this purpose, they undergo a chemical process called hydroxylation (insertion of a hydroxyl group (-OH) in an organic compound) first in the liver and then in the kidneys.
- The first hydroxylation that takes place in the liver converts vitamin D in 25-hydroxyvitamin D [25 (OH) d], which is also known as calcidiol.
- The second hydroxylation takes place mainly in the kidney and forms 1,25-dihydroxy vitamin D [1.25 (OH) 2D], calcitriol. This hormone has several functions in the body such. B. calcium intake, the bone metabolism, the immune response, etc.